Hello! Founder of Glide FTA.

Yes, many of our customers hit the issues you mentioned as they scale spreadsheet-based applications. We built Big Tables for this case: https://www.glideapps.com/big-tables

You keep most of the convenience and programmability of a spreadsheet, but you get Postgres scale and a first-class API (which includes atomic table swapping for updating large datasets). It also supports live updating of any views displaying that data.