I consider such items to be worse and not just because they are objectively worse. Items break and are lost. When you become emotionally attached to an object such as a unique imperfect guitar, you are guaranteed to have sorrow when it is lost (e.g. in a fire).
In any case, the original premise was that such items are better and thus hand made medicine is better too. However, you do not want variations in medicine. During the pandemic, my doctor had a suspicion that the dosages of certain drugs had been lowered by the manufacturers versus what was on the label. That posed a problem for him because he could not properly treat patients if he had no clue what was actually in the pills filling his prescriptions. His suspicion had stemmed from seeing a trend among his patients where the efficacy was dropping in a way consistent with the dosages being lowered, although he was not sure by how much. If he had tried to compensate by prescribing larger dosages, when the manufacturers began to get things right again, his patients would have been taking overdoses. His solution was to switch them to alternative drugs and hope that the manufacturers of those drugs were producing pills that matched their labels. This is why precision is very important when it comes to medicine and the last thing anyone needs are imperfections in drug manufacturing.