I, too, have issues specifically with recipients sitting behind Proofpoint setups. My IP isn't blocked per se, it's just not "trusted" because I don't send enough, so it's permanently stuck in "new untrusted sender" purgatory. I can't even return responses to e-mails that were sent to me from behind Proofpoint. At this point I consider Proofpoint a completely counterproductive piece of garbage product.