Well, security is all I do, and I think the superior security of the Unix config model is a huge myth. And again: I'm a Unix person.
First, there are just as many places to backdoor on a Unix desktop (of comparable functionality) as there are in Windows. The difference is that there's one place to monitor and scan in Win32, and a zillion in Unix --- you literally can't know everything (or even 80%) of what you need to monitor in Unix.
Second, it's not as if the Unix permissions model is any more flexible than the Win32 model. If you can edit files in /etc, you own the box. If you can edit files in ~, you own the user. It's the same scenario in Win32.
Third, the reasons there are "cleaners" and "doctors" for Windows are twofold:
---- (1) Windows users have been sold the bill of goods that they need to keep their registries swept. Unix users don't give a shit. I have Evolution config files from 2000 in my homedir, on my Macbook.
---- (2) Windows users get a disproportionate share of all viruses and trojans, because Windows desktops are more than 90% of the outstanding population of hosts, and are nowhere near tapped out for attackers yet.
As for the rest of it:
* show me a registry subtree on Windows that you think is a bad example of sane, automatable, declarative configuration, and I'll find a comparably bad Unix configuration file.
* every enterprise in the world has a standard Win32 build/replication system that covers the registry, and most of the ones I've seen are homebrew, so all my evidence is that this is a solved problem. On the other hand, a lot of my clients don't have a well-managed automated Solaris build.