JavaScript is weird, but it was specifically made and has evolved entirely for making non blocking, snappy, event driven user interfaces.
Python was not.
Also, you’d end up breaking the very standards that make the web open. If websites only work on 1 browser because it’s the only one that supports Python, then you’ve just lost the open web.
That’s the whole idea around WASM. A standard compile target that’s designed for the sandboxes environment of websites.