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Constrained features can work great in certain niches, imagine using this in a kiosk (where resizing isn't possible).

Yeah, the layout would still resize but it could be non-ideal in some cases as it would be based on media queries for another width.

For the rotation I could process a second layout on the background and switch to it instantly if rotated. Similarly hover effects will be limited. Things affecting visibility of the blocks/layers should work (for menus), small adjustments of layouted text too, but anything that is more complicated won't be. It currently uses a hardcoded hover effect for links.

I believe Netscape worked like this back in the day. (ETA: as in, resizing the window would reload the page.)

Resizing would just reflow (ie re-render it) the page, not reload it.