UUIDs are very wasteful [1]. For most use cases you can replace them with much shorter strings and still have very low chances of collisions [2]
IE
CREATE TABLE foo(
id_ms UNSIGNED BIG INT NOT NULL,
id_ls UNSIGNED BIG INT NOT NULL,
PRIMARY KEY (id_ms, id_ls)
) WITHOUT ROWID;
That works well with UUIDv7 and is just storing 128bits rather than a full string. In most languages it's pretty trivial to turn 2 longs into a UUID and vice versa.