Why eating less slows ageing: this molecule is key
nature.com
nature.com
> A naturally occurring compound involved in digestion lengthens lifespan in flies and makes old mice more youthful.
— Advertising slogan, Kellogg’s 1917
If I do eat early my body takes hours to get to full energy again. It literally makes me tired.
My girlfriend doesn't work that way. And I have no idea why this works so well for me.
It's certainly not the most important meal of the day in general. Especially as a societal meme that came directly from an advertising campaign for a cereal manufacturer.
https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_cite...
154 so far. I'm not sure how to dig into that and answer the question though.
Highly recommend reading this book for folks that are interested in Longevity.
Dr. Longo has also done a few podcasts with Dr. Rhonda Patrick (who might be more known to the audience here) you can checkout
A summary of the diet from the review:
The longevity diet resembles a modified vegan diet in which certain seafood and small amounts of meat and dairy are allowed. It is as much a lifestyle as an eating plan and can be followed for an indefinite amount of time. The guidelines include following a five-day fasting-mimicking diet periodically throughout the year.
Including real fasting in a diet beats any of those fad diets with fake fasting gimmicks.
Is pure Water Fasting superior? Yes. I have done 1 week water fasts, back to back for 4 weeks and lost ~30 lbs.
However, I think fasting mimicking may help adherence for some people.
1: https://www.aacr.org/patients-caregivers/progress-against-ca...
Facetious of course, but the underlying point has merit. Just what part of your life are you extending? Are you extending the healthy, active period, or just dragging out that bit at the end when someone else has to wipe your bottom and feed you apple sauce? Especially with the current topic, it seems very likely to be the latter, and I'd rather eat the other half of my sandwich, and die a few years earlier.
That is the goal of every single person interested in longevity.
I have heard the term "extending healthspan" and to me that's a much better explanation of what people are trying to do.
It's always both. Mortality isn't an independent counter, it's linked to a bunch of predictors that are also predictors of health and autonomy.
In other words, if you "eat the other half", you won't just die younger, you'll also start eating applesauce sooner.
Feel better meant being more active and more social. Obviously my recollection lost all the "literary" qualities that comment had - but I like its message.
1 - Some non-statin antichilesterol drugs work by preventing reabsorption of bile acids, causing them to pass through the bowels. Can this have the positive side-effect of making lithocholic acid precursors more available to the gut flora downstream? See https://en.m.wikipedia.org/wiki/Bile_acid_sequestrant
2 - Does this affect those who underwent surgery to remove the gallbladder? Say, making caloric restriction more or less effective for this population.