With vast discretionary spending, people would be able to sacrifice some pleasures for pleasures related to achieving a long-term impractical goal. Space travel does not have to be the most efficient means of enjoying life to be a human choice.
A colony in Antarctica would be much more practical than one on the Moon, but a Lunar colony is more romantic.
If material trade is not worthwhile, conquest may be somewhat discouraged. (Some people might wish to rule all of humanity or convert/exterminate all heretics, so no distance would be perfectly safe, but a perceived threat in Antarctica would be easier to eliminate than a perceived threat on the Moon or in the Large Magellanic Cloud.)