Which itself seems to be related to the word "guy" as in "guy wire" also related to "guide", "guidance", or "guidelines". Meaning to lead, direct, or conduct. To show the way.

I'd guess this depends on region/demographic, but at least in my circles on the west coast, "guys" is gendered when it's used to describe or identify people in the third person, but it's gender-neutral when used to address a group of people in the second person.

So "the guys" or "how many guys" always refers to men, but "you guys" carries no implication of gender at all. I often hear people address groups consisting entirely of women as "guys", and nobody bats an eye.

In communication there are senders and receivers.

You can receive something a certain way that was not intended by a sender.

It's important to try to understand the intent of the sender. In this case, many cultures sending the message "you guys" don't internally view this as relating to gender.

You could try to change their culture because many people receive it wrong, or you could learn about the culture and try to change the receivers culture.

Sometimes you can't accept the differences because it's perpetuates too much harm.

Where to draw the line is an ongoing and difficult question.