Well I'm a little outside my league on SELinux, but as I understand it, SELinux a way to limit syscalls by configuration.
io_uring operations are similar to syscalls, but not exactly the same thing, so if I've read up correctly, I think SELinux originally may not have covered operations --- if the config allowed you to use io_uring, you could bypass SELinux restrictions, and the easiest/safest thing to do for that is to restrict io_uring. I think this may have been resolved, it looks like there was work on SELinux controls for io_uring back in 2021 [1] that looks like it got merged, but I haven't really followed this. There's also the issue that what happened in Linus's tree 2021 doesn't necessarily reflect what's in common kernels in 2024; some distributions are built from ancient branches.
Based on the language in the pull request, I would think you'd end up needing to have near duplicate policy entries for regular syscalls and io_uring operations, which sounds tedious (but the whole SELinux thing sounds tedious to me, so I'm maybe not the right person to ask :D )
[1] https://lore.kernel.org/lkml/CAHC9VhRJ=fHzMHM6tt8JqkZa4bf0h7...