This is why there’s ideas like the Bussard ramjet, which may not work but try to work around this problem by using in situ mass-energy.
Now I have read that it may be possible to use a powerful magnetic field to assist with slowing down by braking against the interstellar medium, which helps.
The Avatar films have (in spite of very derivative plots) fairly realistic (at least physics wise) interstellar ships. They accelerate using beamed laser propulsion from the Sun and use antimatter rockets to decelerate, then repeat this in reverse to come home. One assumes they somehow recharge at their destination but this is not shown. Too bad all that cool tech is in service to humans who decided to be the bad guys from War of the Worlds.
Still traveling that close to c brings up tons of other problems. Collision with a micrometeorite would be like an atomic explosion, and blue shifting of incident and cosmic background radiation would blast you in the head with x-rays and gamma rays. Those problems would demand more mass for active or passive shielding, and you’re already mass constrained.
All things considered it’s way more practical to go slower — which could still be insanely fast e.g. 0.25c — and figure out how to cryosleep or become an AI that can just turn yourself off for the trip. Cryosleep for humans is a brutally hard biomedical problem but way easier than trying to approach the speed of light. There are other multicellular animals that can do it, albeit much simpler ones, so it’s probably possible.
0.25c allowing for acceleration and deceleration gets you to Centauri in around 25 years and to further star systems with promising exoplanets in hundreds of years.
Then there’s generation ships, but that’s the kind of thing Mormons would do. :)