Yes, one of the many differences (advantages) of NATS JetStream over Kafka: with NATS you can ack explicitly each message individually, and even better if you set your stream to be in 'work-queue' mode it will also automatically (and atomically) delete the ack'd message from the stream (i.e. like a 'proper' queue) another difference with Kafka where you can't delete individual messages in the middle of a stream (only trim the tail end).

You can also 'negative ack' messages, specify a back-off period before the message is re-delivered (because NATS automatically re-delivers un-acked (or nacked) messages) when you can't temporarily process it, or 'term' a message (don't try to re-deliver it, e.g. because the payload is bad), or even 'ask for more time before needing to ack the message (if you are temporarily too slow at processing the message).