The Hohmann transfer is formally the most fuel efficient two-burn transfer. Bi-elliptic transfers require three burns.
*Meaning "large enough for major orbital maneuvers".
On the other hand, neither one is guaranteed to be optimal for continuous thrust maneuvers, which with electric prop are increasingly common.
For these onboard main engines, number of starts is not a concern.
Back when some geosynchronous satellites used solid motors there would be one huge maneuver at apogee to get nearly all the way to GEO (e.g. the Hughes/Boeing 376 spinners). The uncertainty in performance on these maneuvers was quite large so correction maneuvers were always planned afterwards.