I'd add to this and say the probability being against a theory creates a risk of less than thorough dismissals of claims.
You get this all the time with perpetual motion machines. The near certainty of the claim being false leads to confident dismissals that go 'blah, blah, laws of physics, blah blah thermodynamics, therefore can't happen'
The real question to be asking about a claim of a perpetual motion machine is 'Where does the new energy come into being?'.
Citing laws of physics won't help you because any claim to have made a perpetual motion machine is implicitly claiming to be a proof by counterexample that one of those laws is wrong.