Like with 2 of each, or 3 of each, where you play the same waveform through every possible pair of speaker and microphone, you can solve some kind of system of matrix equations to determine the only possible combination of responsiveness at each device at each frequency?
Or do you just need a reference microphone with known characteristics, period, end of story, because math can't do it?
(Obviously from a practical perspective you want the reference microphone... I'm just curious about in theory.)