"I think you'll find it's a little bit more complicated than that."
Windows 3 could run Win32 code:
https://en.wikipedia.org/wiki/Win32s
It's still out there:
https://winworldpc.com/product/win32s/130
It's a good way to get the old tiny fast Freecell on Windows 11. The FREECELL.EXE binary in Win32s runs fine on Windows 11 x86-64. (And on Arm64 come to that.)
And OS/2 could run Win32s:
https://www.os2world.com/wiki/index.php/Win32s
... At least until the final version, 1.30c (IIRC) when MS found a way to nobble it so OS/2 couldn't run it any more.