Hey, discussion of orexin receptor stuff! As someone with clinically-diagnosed insomnia, I've been lucky enough to/unfortunate enough to have to try the orexin receptor antagonist sleep aids for a while. As recent, on-patent drugs, they are very, very expensive ($360/month was the number marked on the receipt slip, not that that means much in the US; I certainly wasn't paying that)... and they work. They really, really do work. I was prescribed them because I tried every single other class of sleep aid on the market and they were mostly ineffective, had massive side effects, or were benzos (temazepam: best sleep of my life, but better not use it for longer than a month!).

This stuff? Orexin receptor antagonists? They work. Holy crap, do they ever work. Sleep quality better than the Z-drugs, great tolerability, no massive disruption going off them... when these things go off-patent they're going to be massive. Sleep quality was not perfect (maybe 80% of "normal"? I don't know) but that is absolutely minor compared to the alternative.

(And for the record, I'm off them now due to other stuff clearing up such that I don't need this level of sleep assistance anymore. Not because I can't afford them.)

I guess that's a long-winded way to say that if you're going to do questionably-advised sleep biohacking, orexin receptors are probably the place to start.