10. Kill Wall Street (etc.)
We now have the technology to completely remake the financial system -- not just make 'banking' or whatever easier online, but a thorough and innovative re-imagining of what the whole thing should even be about.
Information structure is the essence of all cooperative systems, and that means the economics of tomorrow is absolutely about software -- its architecture, its engineering.
The practicalities mean this cannot be tackled directly, but someone needs to think big and work on it (in various ways).