Nah, just create the world at a state where modern medicine can cure cancer, like we're on the slow road to doing.

In the 1800s someone might have asked "if suffering is required and a child is going to die of a systemic infection, maybe the whole project should have been scrapped at the planning phase".

To me it's clear that human flourishing without much suffering is possible in this universe and it's more about knowledge and power to prevent suffering being hard to come by. The kind of knowledge that e.g. could have been written down in ancient religious books or whatever if we had a best possible world.