Not a hindrance, but something like not having a typed database, no auto completion over time, can be a real drawback (I know about django-types).

Finally, in my opinion, the best reason to not use Django is not the project itself (because it will do the job in 99% case), it's because all you learn is tied to Django.

Having learn Pydantic recently was a breed of fresh air, and I would reuse it in lots of projects, not only web projects.