Pixar uses Perforce. Over 1000 users, 12 million ops/day, 40 million changelists, 115 million files, >20 TB data, and accessed by 12,000 cpu renderfarm. If you're dealing with large amounts of binary data it's basically a solved problem and Perforce is the answer. An expensive answer but an answer.

http://www.perforce.com/sites/default/files/storageforfilmas...