Of course there are other ITU tests that work without hidden references, looping or even A/B comparison. They require a much bigger listener pool, are more expensive and take longer, thus used less often during development.
I'll trust actual validated limits of human perception such as 16/48 audio, 1~3dE colour, etc. And techniques used in video encoding like psnr, ssim, etc are also pretty well grounded in science. Also SINAD
But anything involving a human blindly comparing audio is into audiophile pseudoscience territory, no matter how large a cohort of people or how it is executed
No, this is nowhere near pseudoscience, psychoacoustics is an established field of science.
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