The two biggest issues I'd have with Linux full time would be audio and video. I haven't even attempted to run Linux audio in like 5-10 years - it was always so titchy with multiple 'standards' to configure. Video was not quite as bad, as I don't game much so I just needed basic functionality. But now I have multiple 4k monitors, high dpi, and all that jazz, I don't know how big a pain it would be. I just run linux in VMs (standard device drivers and setup) or ssh into a linux server for now.