I am happily experimenting with Typst right now (https://typst.app/ ), which compiles much faster than LaTeX and with a syntax very similar to md, together with nice support for math, figures and advanced settings.
If you are typesetting a research paper or writing a technical book for print publication typst is a great solution, but for a lot folks not having web support is an absolute dealbreaker.
All of this stuff is crazy useful in typesetting. I love markdown, but its missing too many features.