Security has no finish line, unfortunately. But here are a few security-related things Sequoia has that Mac OS X 10.0 did not:
A firewall. VPN support. FileVault and FileVault 2. Secure Empty Trash. Increasingly-secure sandboxing. Library randomization. Address Space Layout Randomization. XProtect. Increasingly-secure versions of Gatekeeper. Increasingly-secure memory management. SIP. Kernel exploit mitigations. New update mechanisms for security patches. APFS and its associated security improvements. Notarization. Read-only system volume. Separation of user data and system files. Activation Lock. Improved system logging and auditing. Signed System Volume. Private Relay. Lockdown Mode. Visual indicators of mic/camera/location use. DriverKit to replace the use of kexts. Secure Enclave for hardware-based root of trust and secrets management.
I'm just someone who pays attention. I imagine actual security experts could list 20+ other improvements off the top of their head.