So what happens if he goes so far that the United States loses or jeopardizes its global dominance? The same states that voted heavily for him would be the first impacted, with massive job losses and higher costs. Coastal states and cities wouldn't be too far behind, with higher costs tempered somewhat by proximity to logistics hubs, and unemployment would be more limited due to the higher concentration of jobs. That is, until our economic dominance falters, at which point our heavily-built-up services industry is likely to fracture and collapse in on itself under the weight of competition from countries like India and China.
All of which is to say that, yes, it's a potential outcome that the United States does dissolve in some fashion, as some states seek to preserve their power and economic control even as the Federal Government loses its mind.
Now then, do I personally think this is the outcome? No, not really. We lack debt to spend frivolously on deficit financing, so there goes that easy out. The stock market is not the economy, and workers will quickly realize that when stocks skyrocket and they're all laid off 2008-style, which would be bad for those with the most to gain (billionaires and Private Equity). I still think there's enough backstops in place to prevent runaway collapse and dissolution...
...although the biggest one of all is a divided Congress. If the GOP gets a trifecta (Executive, both Legislative chambers, and SCOTUS), then there's nothing stopping the full suite of plans from being implemented post-haste, at which point the music very suddenly stops and everyone realizes how screwed we are. Our prior backstops, our allied countries, cannot be depended upon with a President that is vocally supportive of Russia and while they're dealing with their own populism issues.
All in all, my read is that while things are about to get really bad, they're not likely to be maximum bad, if that makes sense. The current world order has always been fragile post-Cold War, and this might be the time for a grand realignment. It'd be a shame to lose our dominance, but no empire lasts forever.