Allowing specification in Python offers very little advantage - in theory you think, hey, I've got hi-lighting, autocompletion, and so on from an IDE. It'll play nice in VCS. Maybe I can interrogate orchestration layers and so on to produce dynamic views.
In practice diagrams are produced by folks who might not want to use or learn python [or golang, their other implementation]. Instead a lean purpose-build DSL, maybe even an extension of graphviz dot, is easier and more portable for some audiences to pick up. Secondly, we can't JUST graft a DSL front-end onto these tools because the styled components are baked into the project.
My personal experience with layout engines is that they work OK for very small architecture diagrams, but become ugly or inelegant at useful scales.
I (and the teams I've worked with) settle on draw.io, either the desktop app, or committed as part of confluence, as the best way to describe intent/design - and rendering graphviz with a style up top for anything dynamic.
Would welcome seeing a true extension to the dot language that can unlock reasoning engines (like to do threat modeling) and render-time styling.