Diet-dependent host metabolite shape gut microbiota to protect from autoimmunity
cell.com
cell.com
>1 too long
Nonetheless, we gain very important and interesting mechanistic insights from this, which truly helps us better understand human pathobiology.
(biochemist)
The bigger question is how do we control the gut microbiota effectively and accurately?
ALSO, I must point out:
>> Consumption of a high-fat, low-carbohydrate ketogenic diet (KD) improves MS-related symptoms in humans
This is a SKEPTICAL claim, as the footnote trial references used do NOT state this.
Some people are ignorant, some people are lazy, some people are addicted, some people straight up don't care
My dad didn't even know the difference between carbs and sugar, as in if his doctor told him to eat 100gr of carbs per day he wouldn't know what's best between sweet potatoes or pure white sugar. It's almost like not knowing you need o2 to breath or water to survive
If you are on the Standard American Diet, and having autoimmune disorders, then improving any diet can 'dampen', and that might be enough.
Don't think anybody thinks diet is a 'cure' of autoimmune disorders, just some improvement.
1. The article does not claim that diet modification cures autoimmunity
2. Autoimmunity is partly but not wholly genetic, and the genetic component usually can’t be described as “a genetic alteration”— it’s more a collection of a large number of interacting genetic predispositions (and that is usually coupled with various environmental and random factors). Either way, diet and genetics interact in many ways.
3. It is not at all surprising (in general) to find that interventions at the level of lipid metabolism result in measurable changes in disease model biomarkers… Although the specifics are very interesting. This is a great paper.
(biochemist)
Which, related to your point about collections of interacting genes: I ran a Promethease report on my genetic data, and it said I had 15-20 different genes associated with an elevated risk of a particular autoimmune disease that I do, in fact, currently suffer from. So in a case like that, I suspect (but obviously can't say for sure) that protective diets have a much harder battle to fight than for someone who doesn't have all those genes.
That's quite the sweeping claim. What are you basing that on?
I just wouldn’t word it as something so simple as “a genetic alteration”. It’s usually more like “a combination of hundreds of genetic predispositions”, which could comprise acquired mutations as well as natural variants of various genes. And that is quite often mixed in with a few dozen environmental or epidemiological factors.