I gave a remote talk a bit earlier this year, and that was the hardest part for me. I didn't quite realize how much I adjusted my speaking based on how the room is reacting. Sometimes my sarcastic humor doesn't land, or it would have landed but I talk way too fast, or people just can't understand what I'm saying and I can see that by looking at peoples' facial expressions.
Probably won't do it again unless there's some kind of emergency. I would have done it in person even this last time, but there was some scheduling conflicts on my end. It's just a lot more fun to do this stuff in person.