I've migrated a couple moderately large projects from pyenv & poetry to uv, and it has been great. The switch was easier than I expected. I uninstalled pyenv after a few weeks, as I realized that uv makes it irrelevant. I've also replaced pipx (which manages Python tools/programs each with their own virtual environment) with uv's tool feature. I used uv for every new Python project. The only thing it's missing that's important for me is support by Dependabot on GitHub. Once Dependabot can update its lock files, I'll be able to uninstall poetry.