It's a bit of a shame that Plague Inc does not support re-infection. Once someone had the disease, they are immune for life.

And the only goal the game really supports is killing everyone, instead of eg going for the largest sustainable population of your organism. (Think more like one of the bugs that cause the common cold, and less like the black death.)

One of these days, someone's going to genetically engineer a virus that spreads easily to infect as many people as possible, but stay dormant for a few years while in this phase, then suddenly it'll turn lethal. Someone from the future might use a time machine to try to come back and gain information about the virus, and then even try to stop its spread once he finds the rogue researcher releasing it at airports, but then will tragically find out that you can't change the timeline, even if you can travel back in time.

Madagascar has closed its ports.