I know, from repeated personal experience, that psychedelics (or mushrooms at least) can be highly effective against even severe depression.
They have been the single most effective anti-depressant that I have ever taken.
Now, I haven't had the depression curing wonder of an experience that some people claim;
It never pulled me out right out of it - but it pulled me back from suicide (on multiple occasions) and a single (rather large) dose is effective for 3 or 4 months before I find myself spiraling back down.
And if we're gonna have a conversation about anti-depressants that are being used despite scant evidence in their favour, perhaps we should start with SSRIs - which not only made my depression worse, but also left me almost asexual for ~20 years.