> The science behind this stuff has always been weak and subjective or due to placebo effects. Give someone a sugar pill and tell them it's psychedelic , and some may actually feel something.

(Replying to the comment that you made before completely rewriting it.)

You're completely wrong about the sugar pill (or at least whether or not it matters) - it's one of the issues with psychedelic medicines: there's no viable placebo at higher doses, and it's the higher doses that seem to have the deepest and longest lasting impact on depression.

In other words, you've never tried a serious dose of acid or shrooms (not to mention dmt) and now you look like a fool to anyone who has.

Most people certainly aren't capable of having the same kind of experience without the substance, goes for all of the ones I mentioned and more.

And while we haven't been able to do the amount of science one could wish for, because of criminalization; there's plenty of experience out there and enough science to understand how the drugs deliver their effect.