Libsodium does this compiler-specific pragmas and attributes (like __attribute__((optimize("O0")))). It's also the cryptographic library mentioned in this study with the smallest number of discovered issues, but:

> "However, we want to note that libsodium is the smallest library that we test with the most limited support for cryptographic primitives. For example, libsodium does not support the elliptic curve secp256; instead,they do all of their elliptic curve operations on curve25519. Therefore, it may be unfair to compare to larger libraries with support for more cryptographic primitives."