At 10m, he gives 3 doomer scenarios: nukes, bioweapons, and nanotech.
He asks: "Is engineering an act of intelligence alone?" He spends ~15m supporting the answer of "lol no". (He also says that science is harder than engineering, and AI will need science to kill us all.)
This isn't to say he's e/acc - at 35m he mentions how AI can continue racism, economic dislocation, classism, etc.
His conclusion is we need to focus on the real problems, not the "human extinction" ones.