CLOS (Common Lisp Object System) is a general OOP standard extension for Common Lisp. A specification was proposed in 1987/88. CLOS was included in the Common Lisp standard and widely implemented by various implementations.
Both were a "system" -> meaning that it is available and programmable also at runtime.
LOOPS is an actual piece of software with a GUI, which integrates into the Interlisp-D development environment.
LOOPS was based on message sending, classes, methods, interactive changes to the object system.
CLOS does not use message sending, but calling generic functions with multi-methods and multiple dispatch.
LOOPS supports Access-oriented Programming with Active Values. Demons can act based on access to objects. CLOS has no direct support for that. Maybe partial (-> :before & :around &:after methods in CLOS).
LOOPS includes a rule-system. CLOS systems have that as extensions. It's not a part of CLOS itself.
LOOPS includes graphical & menu tools to browse and edit objects. CLOS systems have some of that as extensions, depending on the implementation.
LOOPS was a programming system for knowledge-based systems, like Expert Systems. CLOS was not designed for that, but such programming systems were also developed for Common Lisp, some using CLOS. Example: KnowledgeWorks from LispWorks.
LOOPS was later rewritten as CommonLOOPS for Common Lisp. The software "Portable Common LOOPS" (PCL) then was further developed into a portable (and widely ported) and complete prototype implementation of CLOS + MOP.
CLOS and Lisp inherently involve passing objects by reference. If they allow mutation operations, the receiver of a value can mutate it and that's visible to the caller.
Maybe I should be thinking about what sending references to objects in messages means.
Update: my remark was about an earlier posted content, which had an "AI" generated answer. That text has been removed.
EDIT: The comments I was referring to got sneakily edited. Another thing that is not nice to do.
EDIT: still no helpful contribution, just nagging.
CommonLoops was proposed by Xerox to be the OOP system of Common Lisp in the standardization process. It was then decided to design a new system called Common Lisp Object System (CLOS), starting with a merge of the features of New Flavors (MIT/Symbolics) and CommonLoops (Xerox). Xerox implemented CLOS by modifying its CommonLoops implementation, during the standardization process. Thus Portable CommonLoops (PCL) was eventually the prototype CLOS + MOP implementation.