> to bypass the difficulties of working with membrane proteins in the laboratory, the team used AlphaFold to predict interactions between proteins

> AlphaFold predicted that three sperm proteins work together to form a complex. Two of these proteins were previously known to be important for fertility.

https://www.nature.com/articles/nature18448

Here’s the paper linked in the article.

Does anyone have experience using AlphaFold? I don’t have a Nature subscription to see how they specifically accomplished this, but I glanced at the AlphaFold GitHub, and I can’t quite wrap my head around getting it to predict something like this. I’m sure it’s not as simple as prompting ChatGPT with a verbal question.