Fate, Destiny, Logos, God(s), and so on...

It seems that for most of History, we personified luck and lived along that knowledge that something someone wanted some things out of that collective human experience, and thus was guiding events and people to a goal.

I'm wondering what we lost by trying to explain that. For sure, religions and mythologies are still here and kicking, but I'm curious if "Science" will ever get to a point where stuff like this becomes as trivial as "Well, it's God's Plan, I'm just the character in their cosmic drama".

WHat happens when the character want to change the story themselves ?