This statemwnt is true for the people I know who have used it in a recreational manner. This statement is also false for the people I who who have self-treated with it in a controlled setting.
Mescaline is _rough_. And honestly the "you are done with it before it is done with you" thing is 100% true, it is also very long lasting.
I have a plan to try it, DMT, LSD, 2-CB and 5-MeO-DMT before I'm 60, so I guess I'd better get cracking as that isn't far away for me.
The people in this thread saying things like, "they wear off" or dismissing clinical treatment for depression as "suits ripping people off" are delusional and embodying bad stereotypes. Just because you and your bros took mushrooms, had a few laughs and carried on "working hard on saas" or even had a beneficial, religious-type experience doesn't mean that there aren't also risks or that everyone will have a similarly beneficial experience. It's been known for decades -- both empirically and scientifically -- that psychoactive substances can surface latent or bring about psychological issues (e.g. cannabis and schizophrenia) in some people.
Now, I'm not against use of these substances medicinally or recreationally but to pretend like there is no risk and that they're a one-size-fits-all miracle cure is reckless, naive and dumb. As mushrooms and cannabis become more widely available and more powerful (in the latter case), I suspect we'll be hearing a lot more about this class of issues in the coming years.
Overdosing on SSRIs or using them haphazardly could be pretty detrimental too.