That would be a killer feature for me; it's already close with termux etc, but that's not good enough for some things. If it could run Docker as well... Can it on chromeos? Never used Chromeos.
Yes, Android apps in general work fine, apart from those relying on the DRM.
Like everywhere, memory is still what holds things back; I would pay $3k for the Liberty if it had 12-24gb, but he.
Even with such low amount of RAM you can use it as desktop though: https://puri.sm/posts/my-first-year-of-librem-5-convergence/
See also: https://puri.sm/posts/the-danger-of-focusing-on-specs/