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Stupid question but I wonder if the side-effects are a partial contributor to its success: feeling nauseous, upset stomachs, bloating, acid reflux etc? And are there similar, cheaper supplements/drugs that can induce nausea etc?

I know my appetite falls off a cliff if I'm nauseous/have an upset stomach/suffering from reflux.

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From my experience, it is probably contributing, but certainly not the major way glp-1 work. And I certainly had periods where I would overeat while already feeling bloated or nauseated. Glp-1 certainly does something to the body, that regulate eating on hormonal or neuronal level.

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