Of course, it "doesn't work" because people don't keep it up. I started exercising regularly during covid and didn't stop. I cut out all the soda. It works.
Likely, you will at some point revert to unhealthy habits and become fat again.
Long-term weight loss success numbers are abysmal.
Testosterone replacement therapy, highly refined protein powders, nootropics, etc.
We’re all trying to make the best of what’s given, revert mistakes, live longer.
All options are on the table.
That should be very doable for most people. 250 is overweight for everyone under 7 feet tall, and 280 is obese for everyone under 6 foot 9 inches (that's about 99.997% of the population, if my data source is correct). For the vast, vast majority of people 350 pounds would be somewhere in the mid-40s BMI.
If you want to not be fat, exercise and eat fewer calories. Full stop.
The fact that a certain group of individuals don’t have that self control is just evidence that education and public health have a place. Drugs won’t solve that.
These drugs are needed for people with metabolic disorders caused by years of food abuse or poor genetics. It’s not a population wide solution.
Like (a) no shit and (b) the question is why can’t people. Because we know objectively they can’t.
The drugs work by literally solving your self control issue, and to such an extent it works beyond just food.
> By 5 years, more than 80% of lost weight was regained
I think a much better hypothesis is that CICO does work, physically, but there are metabolic, hormonal and mental factors that either predispose towards obesity or make it difficult to escape.
It's a bit like telling gambling addicts to "just stop gambling" or depressed people to "lighten up".
And along comes GLP-1 drugs, where obese people find it easy to lose weight, find new motivation for life, etc. The GLP-1s aren't increasing metabolism, nor are they making people exercise, nor are they making food less available. Yet somehow, a hormonal mediation is greatly successful, hmm.