It's somewhat important to the original spirit of the comment since Acts of God might indeed happen anywhere (1) whereas acts of man might not. For example, disruption caused by on going war in Syria wouldn't be covered by an Act of God clause.
(1) I think that's BS though...there are definitely some places where nature is considerably more stable than others.
US East or US West plus Direct Connect to your own colo space, with AWS for the burst capacity, and your own redundancy for the database servers, might be the best plan if you can't do wide area "over the Internet" database replication. (I might get an extra 10G DC (since I need 1G DC myself) and then have some colo for sale with it in US East/US West later this year.)