JS devs - do everything but write in another language challenge level: Impossible.
Frontend is an obvious one but also using services like CF Workers or Deno Deploy which are optimized for V8. You're going to get better uptime and lower latency than anything else at that cost.
do you mean like reactive data?
You can use other languages that compile to WebAssembly, but it's borderline as it's basically just a VM / self-contained executable that you can pipe to. It's completely isolated from the browser.
"but wasm has to call JavaScript to use browser APIs" WasmGC is shipped in Chrome and Firefox and enabled by default in WebKit nightly
I personally care a lot more about having a confidence-inspiring language and ecosystem.
In my experience with Rust and WASM (with various tools such as Dioxus), I find myself caring a lot more about the WASM ecosystem and browser evolution/improvement.
For example, at bottom, the JS interop feels pretty sub-optimal. Calling this "hcky" might even be deserved: I'm talking about memory serialization between JS-land and WASM-land. As I understand it, we may see significant improvement under the hood in the next few years. (I'm not an expert on the particular proposals, their adoption, etc. Please weigh in if you have a better sense.)
I'm all for having a confidence-inspiring language and ecosystem, don't get me wrong, but it's kind of a non-starter if I can't build at the same pace in Rust as I can in typical web technologies.