If this pep were implemented I suspect it would result in forcing thousands of not tens of thousands of people to spend hours modifying perfectly working code and destroying the ability to run old scientific code without modification. Extremely effective industrial sabotage if it were to be accepted.
It is hard for me to articulate how much peps like this reinforce my desire to never start another python project. Even if this pep is rejected the fact that there are people who would put in the time and effort to write and submit such a PEP tells me that they will do it again, and eventually they might succeed.