Damn straight. One time I wanted to use an ISO with a USB stick and it turned into such a giant pain in the ass that I wrote up all the instructions. I still get a ridiculous amount of traffic on this blog page: https://honeypot.net/2011/10/11/making-dos-usb.html

That was one specific ISO in one specific use case. There’s probably a GUI that does all this automatically now. That one time, though, I would’ve sold a kidney for a dd-able image.