There's no world in which atomized nicotine, glycol/glycerin, and some flavors, is comparable, let alone worse, than inhaling smoldering tobacco leaves. Even the purest, organic tobacco made from the nicest leaves lovingly collected by happy family farmers, is still gonna give you cancer if you burn it and inhale the smoke. That's just chemistry.

The only exception is if the vape juice contains something it "shouldn't", like the vitamin E acetate debacle, but if you put the same wrong things in tobacco, you get the same issue. This problem is avoided entirely with a verified source of ingredients.

Partial combustion products will always contain, at minimum, polycyclic aromatic hydrocarbons, a verified carcinogen. The hotter the conditions, the more complex the precursors, and the more incomplete the reaction is, the more nasty junk you will create. Vaping might or might not be bad, but the chemistries of smoking includes the full set of chemistries of vaping, and then way way more, due to the incomplete combustion of the much larger molecules in plant matter.

Bottom line: probably don't put the volatile reaction products of substances heated above 100°C into your lungs: tobacco smoke, vape, campfire smoke, car exhaust, brake dust, etc. But some reactants are far worse than others.