Yep, there was a physicist who did the math on the Epstein Drive (unfortunate name) in The Expanse and found that it was at the edge of possibility if you use
very efficient lasers, ICF, and D+He3 fuel. There is mention of helium-3 and fuel pellets in the books, so it sounds like that was the idea.
The biggest un-realism in The Expanse is the lack of huge heat-sinks, at least in the show. (They aren't mentioned in the books but I assumed they'd be there.) Without heat-sinks even if the drives were >95% efficient the ship would melt. Also in the show the thrust plumes from the engines are portrayed as looking like grill flames. In reality they'd look more like beams of light fading off into space.