I have tried oxycodone (40 mg, went way above 80 mg too) and it did not make me high at all, people talk about a state of bliss and whatnot but I have never experienced it.

Most substances do not affect me the way they affect others; I have depression & anxiety and I have tried almost all antidepressants (along with mood stabilizers) to no effect.

I suspect it may have to do with my brain lesions (I have MS), but I am not quite sure.

That said, opiates do help with my physical symptoms, and only them, unfortunately.

> people like me need prescription strength (30-60mg) codeine to feel any benefits at all, and don't feel remotely high from it.

It is interesting though. Oxycodone is way stronger than codeine, and 80 mg is considered a very high dose yet it does not make me high, with or without tolerance.